Interests: Focuss on biophysics of P2X receptors and Piezo channels. Developpement of new molecular tools targeting P2X7 receptors.

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Technical Skills: Patch-clamp electrophysiology, molecluar biology, chemcial synthesis

 References: 

Dunning K, Martz A, Peralta FA, Cevoli F, Boué-Grabot E, Compan V, Gautherat F, Wolf P, Chataigneau T, Grutter T.* (2021). P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation. Int J Mol Sci. 2021 22(12):6542

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Harkat, M., Peverini, L., Cerdan, A.H., Dunning, K., Beudez, J., Martz, A., Calimet, N., Specht, A., Cecchini, M., Chataigneau T. & Grutter T.* (2017). On the permeation of large organic cations through the pore of ATP-gated P2X receptors. Proc. Natl. Acad. Sci. USA 114, E3786-3795.

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Habermacher, C., Martz, A, Calimet, N., Lemoine, D., Peverini, L., Specht, A., Cecchini, M. & Grutter, T.* (2016) Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel. eLife 5, e11050.

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Lemoine, D., Habermacher, C., Martz, A., Méry, P.F., Bouquier, N., Diverchy, F., Taly, A., Rassendren, F., Specht, A. & Grutter, T.* (2013) Optical control of an ion channel gate. Proc. Natl. Acad. Sci. USA 110, 20813-20818.

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Jiang, R., Taly, A., Lemoine, D., Martz, A., Cunrath, O. & Grutter, T.* (2012) Tightening of the ATP-binding sites induces the opening of P2X receptor channels. EMBO J. 31, 2134-2143.