INSTITUTE FOR RESEARCH ON CANCER AND AGING IN NICE
We are studying the implication of the ATP/P2RX7 pathways in lung diseases.
We showed using mouse models that P2RX7-expressing immune cells are important actor to set up anti tumor and anti fibrotic immune responses. We developped and patented a positive modulator of P2RX7 (HEI3090) that attenuates lung fibrosis and when combined to classical immunotherapies cures mice with lung tumors.
Thanks to 3D co culture of human cells and culture of ex vivo lung human tissues, we want to demonstrate that HEI3090 can be used in human to treat lung diseases.
Réferences:
Serena Janho dit Hreich, Thierry Juhel, Sylvie Leroy, Alina Ghinet, Frederic Brau, Véronique Hofman, Paul Hofman, Valérie Vouret-Craviari. Activation of the P2RX7/IL-18 pathway in immune cells attenuates lung fibrosis. eLife, 2024
Serena Janho dit Hreich, Thierry Juhel, Paul Hofman, Valérie Vouret-Craviari. Protocole for evaluating in vivo the activation of the P2RX7 immunomodulator. Biological Procedures on line, 2023. 25:1
Serena Janho dit Hreich, Paul Hofman, Valérie Vouret-Craviari. The role of IL-18 in P2RX7-mediated antitumor immunity. International Journal of Molecular Sciences, 2023. 24:9235.
Laetitia Douguet, Serena Janho dit Hreich, Jonathan Benzaquen, Laetitia Seguin, Thierry Juhel, Xavier Dezitter, Christophe Duranton, Bernhard Ryffel, Jean Kanellopoulos, Cecile Delarasse, Nicolas Renault, Christophe Furman, Germain Homerin, Chloé Féral, Julien Cherfils-Vicini, Régis Millet, Sahil Adriouch, Alina Ghinet, Paul Hofman and Valérie Vouret-Craviari. Small-molecule P2RX7 activator sensitizes tumor to immunotherapy and vaccinates mouse against tumor re-challenge. Nature Communications, 2021. 12:653
Jonathan Benzaquen, Serena Janho Dit Hreich, Simon Heeke, Thierry Juhel, Salomé Lalvee, Serge Bauwens, Simona Saccani, Philippe Lenormand, Véronique Hofman, Mathilde Butori, Sylvie Leroy, Jean-Philippe Berthet, Charles-Hugo Marquette, Paul Hofman and Valérie Vouret-Craviari. P2RX7B is a new theranostic marker for lung adenocarcinoma patients. Theranostics, 2020, 10 :10849-10860.
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