Institut des Maladies Neurodégénératives
CNRS UMR 5293
Our current research interests are to better understand:
1) roles of neuronal versus glial P2X receptors in neuronal activity/plasticity, neuroinflammation and several brain diseases .
2) mechanisms of regulaiton P2X function and trafficking
3) Role of P2X in developement.
Technical skills: Electrophysiology, cellular and biochemical approaches and behavior on transgenic mice models and xenopus model for developmental biology
References:
Bertin E, Martinez A, Fayoux A, Carvalho K, Carracedo S, Fernagut PO, Koch-Nolte F, Blum D, Bertrand SS and Boué-Grabot E (2022) Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice. Mol Cell Life Sci 79:431 doi : 10.1007/s00018-022-04461-5
The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos Karine Massé K, Surinder Bhamra S, Christian Paroissin C, Lilly Maneta-Peyret L, Boué-Grabot E, Jones AE (2021) Communications biology 4(1):1158. doi: 10.1038/s42003-021-02688-9
Bertin E, Deluc T, Pilch KS, Audrey Martinez A, Pougnet JT, Doudnikoff E, Allain AE, Bergmann P, Russeau M, Toulmé E, Bezard E, Koch-Nolte F, Séguéla P, Lévi S, Bontempi B, Georges F, Bertrand S, Nicole O and Boué-Grabot E. (2021) Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice Mol Psy 26, 629–644 DOI: 10.1038/s41380-019-0641-8 ;Epub 2020 Jan 8
Pougnet J-T, Toulmé E, Martinez A, Choquet D, Hosy E, and Boué-Grabot E. (2014) ATP P2X receptors down-regulate AMPA receptor trafficking and postsynaptic efficacy in hippocampal neurons. Neuron 83(2):417-430. doi: 10.1016/j.neuron.2014.06.005. PMID: 25033184
Blanchard C, Boué-Grabot E and Masse K. (2019) Comparative embryonic spatio-temporal expression profile map of the Xenopus P2X receptor family. Front Cell Neurosci 2019 13:340, doi: 10.3389/fncel.2019.00340