UMR 1327 Ischemia
Our team is interested in the involvement of purinergic signalling in ischemia-reperfusion injury in different pathophysiological contexts.
Technical skills: Cell culture, biochemistry, molecular biology, electrophysiology, cell sorting, animal models, purification and analysis of extracellular vesicles.
References:
Chadet S, Allard J, Brisson L, Lopez-Charcas O, Lemoine R, Heraud A, Lerondel S, Guibon R, Fromont G, Le Pape A, Angoulvant D, Jiang LH, Murrell-Lagnado R, Roger S. P2x4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition. Oncogene. 2022 May;41(21):2920-2931. doi: 10.1038/s41388-022-02297-8. Epub 2022 Apr 11.
BRISSON L., CHADET S., LOPEZ-CHARCAS O., JELASSI B., TERNANT D., CHAMOUTON J., LERONDEL S., LE PAPE A., COUILLIN I., GOMBAULT A., TROVERO F., CHEVALIER S., BESSON P., JIANG L.-H. , ROGER S. # P2X7 receptor promotes mouse mammary cancer cell invasiveness and tumour progression, and is a target for anticancer treatment. Cancers. 2020, 12, 2342; doi:10.3390/cancers12092342.
DĂNILĂ M.-D., PIOLLET M., PIOLLET O.-M., ANGOULVANT D., LEFORT C., CHADET S., ROGER S., MUNTEAN M.-D., IVANES F. Modulation of P2Y11-related purinergic signaling in inflammation and cardio-metabolic diseases. Eur J Pharmacol. 2020, June 5, 876; 173060.
KHALID M., BRISSON L., TARIQ M., HAO Y., GUIBON R., FROMONT G., MORTADZA S.A.S., MOUSAWI F., MANZOOR S., ROGER S. *# & JIANG L.-H. *#. Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells. Oncotarget. 2017 Jun 6;8(23):37278-37290.
CHADET S., IVANES F., BENOIST L., SALMON-GANDONNIÈRE C., GUIBON R., VELGE-ROUSSEL F., BABUTY D., BARON C., ROGER S. & ANGOULVANT D. Hypoxia/reoxygenation inhibits P2Y11 receptor expression and its immunosuppressive activity in human dendritic cells. J Immunol. 2015. Jul 15;195(2):651-60.
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